产品名称

Myriocin from Mycelia sterilia

一般描述

Fungal metabolite with potent immunosuppressant activity.

别 称

ISP-I, Thermozymocidin

纯 度

≥98%(HPLC)

CAS NO.

35891-70-4

分子式

C₂₁H₃₉NO₆

分子量

401.54

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄白色粉末

l  生物学信息

生物活性/药理作用

Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.

应 用

Myriocin from Mycelia sterilia has been used as an inhibitor of sphingolipid or ceramide biosynthesis in various studies.

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov