产品名称

Narasin(甲基盐霉素) from Streptomyces auriofaciens

一般描述

Highly specific inhibitor of protein kinase C (IC50 = 50 nM)

别 称

Narasin A; Monteban

纯 度

≥98%(HPLC)

CAS NO.

55134-13-9

分子式

C⁴³H⁷²O¹¹

分子量

765.03

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄白色粉末

溶解性(25°C)

乙醇

≥5mg/mL

l  生物学信息

生物活性/药理作用

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na₊, K₊, and H+ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H₊ concentration on the inside of the Gram-positive cell. Therefore, the H₊ ATPase pump is activated to transport out excess H₊. The cell is depleted of its energy resources and reduces fermentative functions and cell division.

应 用

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov