产品名称

Chromomycin A3 from Streptomyces griseus(色霉素A3 来源于灰色链霉菌)

一般描述

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities.

纯 度

≥95%(HPLC)

CAS NO.

7059-24-7

分子式

C⁵⁷H⁸²O²⁶

分子量

1183.25

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色至黄橙色粉末

溶解性(25°C)

乙醇

≥10mg/mL

l  生物学信息

生物活性/药理作用

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. It serves as a fluorescent DNA stain. It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks  macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

应 用

Chromomycin A3 from Streptomyces griseus has been used as a reagent in flow sorting. It has also been used to stain spermatozoa to evaluate the sperm nuclear chromatin integrity.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov