产品名称

Nikkomycin Z from Streptomyces tendae

一般描述

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.

别 称

Nikkomycin Z; Neopolyoxin C; Nikkomycin

纯 度

≥90%(HPLC)

CAS NO.

59456-70-1

分子式

C²⁰H²⁵N⁵O¹⁰

分子量

495.44

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄白色粉末

溶解性(25°C)

水

~5mg/mL

l  生物学信息

生物活性/药理作用

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

应 用

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov