产品名称

Radicicol(根赤壳霉素) from Diheterospora chlamydosporia

一般描述

Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase.

别称

Monorden, [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

纯 度

≥98%(HPLC)

CAS NO.

12772-57-5

分子式

C¹⁸H¹⁷ClO⁶

分子量

364.78

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色粉末

溶解性(25°C)

乙醇

≥5mg/mL

l  生物学信息

生物活性/药理作用

Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2.It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov