产品名称

Kirromycin from Streptomyces collinus

一般描述

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.

别 称

Antibiotic Myc-8003, Mocimycin

纯 度

≥90%(HPLC)

CAS NO.

50935-71-2

分子式

C⁴³H⁶⁰N²O¹²

分子量

796.94

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色粉末

l  生物学信息

生物活性/药理作用

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA

应 用

Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov