Antipain dihydrochloride from microbial source
商品编号：
S1409
备注：
国外库存，货期2-4周，具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | Antipain dihydrochloride from microbial source(抗蛋白酶素二盐酸盐来源于微生物源) |
一般描述 | Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. |
别 称 | N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe |
CAS NO. | 37682-72-7 |
分子式 | C27H44N10O6· 2HCl | 分子量 | 677.62 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至黄色和淡淡米色至米色冻干粉末 |
溶解性(25°C) | DMSO | soluble |
乙醇 | soluble |
水 | ≥35mg/mL |
l 生物学信息 |
生物活性/药理作用 | Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. |
应 用 | Concentrations for 50% inhibition (μg/ml): papain, 0.16 trypsin, 0.26 cathepsin A, 1.19 cathepsin B, 0.59 cathepsin D, 125 plasmin, >93 chymotrypsin and pepsin, >250 It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM |
l 存储 |
存储温度 | −20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
