Leptomycin B solution from Streptomyces sp.
商品编号：
S1412
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S1412-2X0.5UG
有货
1036
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S1412-5X0.5UG
有货
2275
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+
S1412-10X0.5UG
有货
3563
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备注：
国外库存，货期2-4周，具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | Leptomycin B solution from Streptomyces sp(来普霉素B 溶液来源于链霉菌属) |
一般描述 | Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, MPF, IκB, PKA and MEK. |
别 称 | Leptomycin B; Mantuamycin; |
纯 度 | ≥95%(HPLC) | CAS NO. | 87081-35-4 |
分子式 | C33H48O6 | 分子量 | 540.73 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 无色至浅黄色溶液,(甲醇:水 = 7:3) |
l 生物学信息 |
生物活性/药理作用 | Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region. |
l 存储 |
存储温度 | −20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
