产品名称

普伐他汀钠(Pravastatin sodium)

一般描述

Pravastatin sodium is a competitive, water-soluble HMG-CoA reductase inhibitor. Inhibits cholesterol synthesis in  vivo (Ki ～1 nM).

别名

(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,  δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic  acid sodium hydrate, Eptastatin sodium salt hydrate

纯 度

≥98%(HPLC)

CAS NO.

81131-70-6

分 子 式

C²³H³⁵O⁷Na·xH²O

分 子 量

446.51 (anhydrous basis)

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解度(25℃)

DMSO

≥80mg/mL

乙醇

≥80mg/mL

水

≥10mg/mL

l  生物学信息

生物活性/药理作用

Pravastatin Sodium is the sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of  HMG-CoA to mevalonate, a key step in cholesterol synthesis.Inhibits cholesterol synthesis in vivo (Ki ～1 nM).This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of  the isoprenylation of Ras and Rho GTPases and related signaling cascades.

l  包装与存储

包 装

250mg;1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    S  M Singhvi et.al British journal of clinical pharmacology, 29(29), undefined  (1990-2-1).

2.  Takeshi  Matsuoka et.al Journal of lipid research, 53(53), undefined (2012-6-21).

3.  https://ncit.nci.nih.gov.