产品名称

昂丹司琼(Ondansetron)

一般描述

Ondansetron is a carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

别 称

(RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one; 恩丹西酮;奥旦西隆;翁丹色创;翁丹西隆;翁旦斯隆;  GR 38032F

纯 度

≥99% (HPLC)

CAS NO.

99614-02-5

分子式

C¹⁸H¹⁹N³O

分子量

293.36

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

l  生物学信息

生物活性/药理作用

Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serontonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema. The temporal relationship between the emetogenic action of emetogenic drugs and the release of serotonin, as well as the efficacy of antiemetic agents suggest that chemotherapeutic agents release serotonin from  the enterochromaffin cells of the small intestine by causing degenerative changes in the GI tract.The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT3 receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.

Ondansetron is a carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.   http://www.drugbank.ca/drugs/DB00904

2.   https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov/mesh