产品名称

Sunitinib Malate(苹果酸舒尼替尼)

一般描述

Sunitinib Malate is a multi-targeted RTK inhibitor. Sunitinib blocks the tyrosine kinase activities of VEGFR2, PDGFRb, and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of FLT3.

别 称

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide   (2S)-2-hydroxybutanedioic acid (1:1) salt;SU011248 L-malate salt; 苹果酸苏尼替尼;

纯 度

≥99% (HPLC)

CAS NO.

341031-54-7

分子式

C²²H²⁷FN⁴O² · C⁴H⁶O⁵

分子量

532.56

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

橙色至黄色固体

溶解度(25℃)

DMSO

≥10 mg/mL

Ethanol

Very slightly soluble

Water

Very slightly soluble

l  生物学信息

生物活性/药理作用

Sunitinib Malate is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    https://www.ncit.nci.nih.gov

2.    https://www.ncbi.nlm.nih.gov