产品名称

依托咪酯(Etomidate)

一般描述

Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage.

化学名称

(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; R16659; Amidate

纯 度

≥99% (HPLC)

CAS NO.

33125-97-2

分子式

C¹⁴H¹⁶N²O²

分子量

244.29

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解度(25℃)

DMSO

≥40mg/mL

乙醇

≥40mg/mL

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia. Etomidate is an imidazole compound that appears to depress CNS function via GABA. Duration of action is intermediate between thiopental and  methohexital, and recovery from a single dose is rapid with little residual depression. Like the barbiturates and propofol, etomidate is does not induce analgesia. Etomidate induces unconsciousness within one circulation time. Recovery is rapid as a result of extensive redistribution and rapid   metabolism.

Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads  to membrane hyperpolarization.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov