产品名称

西尼地平(Cilnidipine)

一般描述

Cilnidipine is a calcium channel blocker. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function.

别 称

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester; FRC 8653

纯 度

≥99%(HPLC)

CAS NO.

132203-70-4

分子式

C²⁷H²⁸N²O⁷

分子量

492.52

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色固体

溶解度(25℃)

DMSO

≥50mg/mL

乙醇

≥10mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Cilnidipine is a slow-acting Ca₂₊ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca₂₊ channels in vascular smooth muscle and N-type Ca₂₊ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been ed to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    https://www.ncbi.nlm.nih.gov