产品名称

替加氟(Tegafur)

一般描述

Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.

别 称

5-Fluoro-1-(tetrahydro-2-furyl)uracil; Ftorafur

纯 度

≥98% (HPLC)

CAS NO.

17902-23-7

分子式

C⁸H⁹FN²O³

分子量

200.17

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解度(25℃)

DMSO

≥35mg/mL

乙醇

≥5mg/mL

水

≥5mg/mL

l  生物学信息

生物活性/药理作用

Tegafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450   enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    https://ncit.nci.nih.gov

2.   https://www.ncbi.nlm.nih.gov