产品名称

拉米夫定(Lamivudine)

一般描述

Lamivudine is a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV.

别 称

2′,3′-Dideoxy-3′-thiacytidine; 3TC, Epivir-HBV, Epivir, Heptovir, Zeffix

纯 度

≥99%(HPLC)

CAS NO.

134678-17-4

分子式

C⁸H¹¹N³O³S

分子量

229.26

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解度(25℃)

DMSO

≥45mg/mL

乙醇

insoluble

水

≥45mg/mL

l  生物学信息

生物活性/药理作用

Lamivudine is a nucleoside reverse tranase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse tranase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated  nucleoside analogue prevents the formation of the 5' to 3' phosphodiester age essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Lamivudine is a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites,  lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV,  L-TP inhibits HIV-1 reverse tranase (RT) via DNA chain termination  after incorporation of the nucleoside analogue into viral DNA. In HBV,  incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain  termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and  beta, and mitochondrial DNA polymerase.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov