产品名称

沙利度胺(Thalidomide)

一般描述

Thalidomide is a piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays   immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR  NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

别 称

(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

纯 度

≥99% (HPLC)

CAS NO.

50-35-1

分子式

C¹³H¹⁰N²O⁴

分子量

258.23

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解度(25℃)

DMSO

≥50mg/mL

乙醇

~2mg/mL

水

insoluble

l  生物学信息

生物活性/药理作用

Thalidomide is an immunomodulatory agent with a spectrum of activity that is not fully characterized. Thalidomide is racemic — it contains both left and right handed isomers in equal amounts: one enantiomer is effective against morning sickness, and the other is   teratogenic. The enantiomers are converted to each other in vivo. That is, if a human is given D-thalidomide or L-thalidomide, both isomers can be found in the serum. Hence, administering only one enantiomer will not prevent the teratogenic effect in humans.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov