产品名称

迈瑞替尼甲磺酸盐(Osimertinib Mesylate)

别 称

AZD9291 (Mesylate)

纯 度

≥99% (HPLC)

CAS NO.

1421373-66-1

分子式

C²⁹H³⁷N⁷O⁵S

分子量

595.719

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色至黄色固体

l  生物学信息

生物活性/药理作用

Osimertinib(AZD9291) Mesylate the Methanesulfonic acid salt of Osimertinib(AZD9291). Osimertinib is a third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral   administration, osimertinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. AZD9291 preferentially inhibits mutated forms of EGFR including T790M, a secondarily-acquired resistance mutation, and may have enhanced anti-tumor effects in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov

4.   https://livertox.nlm.nih.gov