产品名称

尼美舒利(Nimesulide)

一般描述

Nimesulide is a nonsteroidal antiinflammatory drug (NSAID) with relative specificity for COX-2.

别 称

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

纯 度

≥99%(HPLC)

CAS NO.

51803-78-2

分子式

C¹³H¹²N²O⁵S

分子量

308.31

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色固体

溶解度(25℃)

DMSO

≥50mg/mL

乙醇

Slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Nimesulide is a nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory   prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks).Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov