产品名称

吲哚美辛(Indometacin)

一般描述

Indomethacin is a non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also   inhibits the motility of polymorphonuclear leukocytes.

别 称

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

纯 度

≥98%(HPLC)

CAS NO.

53-86-1

分子式

C¹⁹H¹⁶ClNO⁴

分子量

357.79

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至淡黄色固体

溶解度(25℃)

DMSO

≥50mg/mL

乙醇

≥20mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Indomethacin is a synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin  inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov