产品名称

阿达帕林钠(Adapalene sodium salt)

一般描述

Adapalene is a topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene .

别 称

6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid, 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid sodium salt;

纯 度

≥98%(HPLC)

CAS NO.

911110-93-5

分子式

C²⁸H²⁷NaO³

分子量

434.510

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解度(25℃)

DMSO

N/A

乙醇

Insoluble

水

N/A

l  生物学信息

生物活性/药理作用

Adapalene is a topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene . This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation.

Biochemical and pharmacological profile   studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which   represent important features in the pathology of acne vulgaris.

l  包装与存储

包 装

50mg; 250mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov