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5-Fluorouracil

商品编号: TL0053
图示 货号 库存 价格(¥) 数量

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详细介绍

l  基本信息

产品名称

5-氟尿嘧啶(5-Fluorouracil)

一般描述

5-Fluorouracil is a pyrimidine analog that   is an antineoplastic antimetabolite. It interferes with DNA synthesis by   blocking the thymidylate synthetase conversion of deoxyuridylic acid to   thymidylic acid.

别 称

2,4-Dihydroxy-5-fluoropyrimidine;5-Fluoro-2,4(1H,3H)-pyrimidinedione;   5-FU; Fluorouracil; NSC 19893

纯 度

≥98%(HPLC)

CAS NO.

51-21-8

分子式

C4H3FN2O2

分子量

130.08

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥25mg/mL

乙醇

Sparingly soluble

Sparingly soluble

l  生物学信息

生物活性/药理作用

Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different   mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov