产品名称

富马酸喹硫平(Quetiapine fumarate)

一般描述

Quetiapine fumarate is a dibenzothiazepine and antipsychotic agent.

别 称

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate; ICI-204636

纯 度

≥99%(HPLC)

CAS NO.

111974-72-2

分子式

C²¹H²⁵N³O²S · 0.5C⁴H⁴O⁴

分子量

441.54

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25℃)

DMSO

≥35mg/mL

乙醇

Sparingly soluble

水

Sparingly soluble

l  生物学信息

生物活性/药理作用

Quetiapine Fumarate is the fumarate salt form of quetiapine, a dibenzothiazepine derivative with antipsychotic  property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine fumarate also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov