产品名称

盐酸利多卡因一水合物(Lidocaine hydrochloride monohydrate)

一般描述

Lidocaine hydrochloride monohydrate is the hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics.

别 称

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate;  Lidocaine hydrochloride monohydrate;Lignocaine hydrochloride monohydrate; Xylocaine hydrochloride monohydrate

纯 度

≥99%(HPLC)

CAS NO.

6108-05-0

分子式

C¹⁴H²²N²O · HCl · H²O

分子量

288.81

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Lidocaine Hydrochloride is the hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated  Na₊ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na₊. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation.  Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov