Cyclosporin A
商品编号:
TL0067
备注:
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详细介绍
l 基本信息 |
产品名称 | 环孢霉素A(Cyclosporin
A) |
一般描述 | Cyclosporin A is a cyclic undecapeptide
from an extract of soil fungi. It is a powerful immunosupressant with a
specific action on T-lymphocytes. |
别 称 | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)];
Antibiotic;S 7481F1; Cyclosporine; Ciclosporin; 环孢素A; |
纯 度 | ≥99%(HPLC) | CAS NO. | 59865-13-3 |
分子式 | C62H111N11O12 | 分子量 | 1202.61 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | ≥50mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Cyclosporine is a natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The
exact mechanism of action of cyclosporine is not known but may involve
binding to the cellular protein cytophilin, resulting in inhibition of the
enzyme calcineurin. This agent appears to specifically and reversibly inhibit
immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary
target. Cyclosporine also inhibits lymphokine production and release. |
l 包装与存储 |
包 装 | 250mg; 1g |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |