产品名称

多韦替尼乳酸盐(Dovitinib lactate)

一般描述

Dovitinib Lactate is lactate salt of  Dovitinib with potential antineoplastic activity.

别 称

(3E)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one;2-hydroxypropanoic  acid;hydrate; TKI258; Dovitinib lactate monohydrate;

纯 度

≥98%(HPLC)

CAS NO.

915769-50-5

分子式

C²⁴H²⁹FN⁶O⁵

分子量

500.531

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄绿色或绿色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~1mg/mL

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Dovitinib Lactate is the orally  bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast  growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor;  fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

l  包装与存储

包 装

5mg; 100mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov