产品名称

达沙替尼(Dasatinib)

一般描述

Dasatinib is a pyrimidine and thiazole derived antineoplastic agent and protein kinase inhibitor of BCR-ABL kinase.

别 称

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;  Sprycel; BMS-354825;

纯 度

≥99%(HPLC)

CAS NO.

302962-49-8

分子式

C²²H²⁶ClN⁷O²S

分子量

488.007

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色至黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Very slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Dasatinib Anhydrous is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the  resistance to imatinib of chronic myeloid leukemia (CML) cells harboring  BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or of the endogenous protein and by way of virally-encoded kinase genes.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov