产品名称

伊马替尼(Imatinib)

一般描述

Imatinib is an antineoplastic agent that  inhibits the Bcr-Abl fusion protein tyrosine kinase.

别 称

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;  Sti-571;Cgp 57148;

纯 度

≥99% (HPLC)

CAS NO.

152459-95-5

分子式

C²⁹H³¹N⁷O

分子量

493.615

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色固体

溶解性(25℃)

DMSO

≥25mg/mL

乙醇

Very slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors  and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit  and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in  malignant cells of Philadelphia-positive (Ph₊) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov