产品名称

舒尼替尼(Sunitinib)

一般描述

Sunitinib is an indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity.

别 称

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;  SU-11248; Sutent;

纯 度

≥99%(HPLC)

CAS NO.

557795-19-4

分子式

C²²H²⁷FN⁴O²

分子量

398.482

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

橙色或黄色固体

溶解性(25℃)

DMSO

≥20mg/mL

乙醇

Very slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Sunitinib is the orally bioavailable an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation.  This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3  (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov