产品名称

苹果酸卡博替尼(Cabozantinib Malate)

一般描述

Cabozantinib Malate(苹果酸卡博替尼) is an orally bioavailable, small molecule receptor tyrosine kinase (RTK)  inhibitor with potential antineoplastic activity.

别 称

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic  acid; Cabozantinib S-malate;  Cabometyx;  BMS 907351 S-malate; BMS-907351 S-malate

纯 度

≥98%(HPLC)

CAS NO.

1140909-48-3

分子式

C³²H³⁰FN³O¹⁰

分子量

635.601

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several  RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1),  2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like  tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor  growth and angiogenesis, and eventually lead to tumor regression.

l  包装与存储

包 装

25mg; 100mg; 500mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov