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5'-Deoxy-5-fluorouridine

商品编号: TL0099
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详细介绍

l  基本信息

产品名称

5'-脱氧-5-氟尿苷(5'-Deoxy-5-fluorouridine)

一般描述

Doxifluridine(5'-脱氧-5-氟尿苷) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.

别 称

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione;  Doxifluridine;Furtulon; 5'-Dfur

纯 度

≥98%(HPLC)

CAS NO.

3094-09-5

分子式

C9H11FN2O5

分子量

246.194

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥40mg/mL

乙醇

N/A

N/A

l  生物学信息

生物活性/药理作用

Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid  degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase.  5-FU interferes with DNA synthesis and subsequent cell division by reducing  normal thymidine production and interferes with RNA tranion by competing with uridine triphosphate for incorporation into the RNA strand.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov