产品名称

塞来昔布(Celecoxib)

一般描述

Celecoxib(塞来昔布)  is a pyrazole derivative and selective COX-2 inhibitor.

别 称

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide; 塞来考昔  ;Celebrex; Celebra; Onsenal;

纯 度

≥99%(HPLC)

CAS NO.

169590-42-5

分子式

C¹⁷H¹⁴F³N³O²S

分子量

381.373

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥25mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Celecoxib, a selective cyclooxygenase-2  (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug  (NSAID). Celecoxib is used to treat rheumatoid arthritis, osteoarthritis, and  familial adenomatous polyposis (FAP). Because of its lack of platelet  effects, celecoxib is not a substitute for aspirin for cardiovascular  prophylaxis. It is not known if there are any effects of celecoxib on platelets that may contribute to the increased risk of serious cardiovascular thrombotic adverse events associated with the use of celecoxib. Inhibition of  PGE2 synthesis may lead to sodium and water retention through increased fluid  reabsorption in the renal medullary thick ascending loop of Henle and perhaps other segments of the distal nephron. In the collecting ducts, PGE2 appears  to inhibit water reabsorption by counteracting the action of antidiuretic hormone.

Celecoxib is a nonsteroidal  anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2  inhibition may result in apoptosis and a reduction in tumor angiogenesis and  metastasis.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov