产品名称

RG7112

一般描述

RG7112 is an orally bioavailable and selective p53-MDM2 inhibitor.

别 称

[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone; CHEMBL2386346; RO-5045337;RG-7112

纯 度

≥98%(HPLC)

CAS NO.

939981-39-2

分子式

C³⁸H⁴⁸Cl²N⁴O⁴S

分子量

727.786

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

MDM2 Antagonist RG7112 (RO5045337) is an MDM2 (human homolog of double minutes-2; HDM2) antagonist with potential  antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the tranional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the tranional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the  p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.

l  包装与存储

包 装

5mg; 25mg;

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov