产品名称

雷尼酸锶(Strontium Ranelate)

一般描述

Strontium ranelate is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee.

别 称

distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate; Protelos; Protos; Distrontium renelate;  Osseor

纯 度

≥99%(HPLC)

CAS NO.

135459-87-9

分子式

C¹²H⁶N²O⁸SSr²

分子量

513.486

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

In general, it is believed that strontium ranelate is capable of affecting a rebalance in bone turnover in favour of bone formation by: (1) increasing osteoblast differentiation from progenitors, osteoblast activity and survival, as well as regulating osteoblast-induced osteoclastogenesis, and (2) decreasing osteoclast differentiation and  activity, as well as increasing osteoclast apoptosis [A31541]. It has also been shown that strontium ranelate is capable of improving and strengthening various components of overall bone tissue quality like bone mineral density and bone microarchitecture [A31541, A31542, A31553].

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov