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详细介绍
l 基本信息 |
产品名称 | 培美曲塞(Pemetrexed) |
一般描述 | Pemetrexed(培美曲塞) is a synthetic pyrimidine-based antifolate. |
别 称 | (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; Alimta |
纯 度 | ≥98%(HPLC) | CAS NO. | 137281-23-3 |
分子式 | C20H21N5O6 | 分子量 | 427.417 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至类白色固体 |
l 生物学信息 |
生物活性/药理作用 | Preclinical studies have shown that
pemetrexed inhibits the in vitro growth of mesothelioma cell lines (MSTO-211H, NCI-H2052). Studies with the MSTO-211H mesothelioma cell line
showed synergistic effects when pemetrexed was combined concurrently with cisplatin. Pemetrexed is a synthetic pyrimidine-based
antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase
(TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate
(dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. |
l 包装与存储 |
包 装 | 50mg; 250mg; 1g |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
