产品名称

异丙肾上腺素(Isoproterenol)

一般描述

Isoproterenol(异丙肾上腺素) is a synthetic catechol compound and potent beta adrenergic agonist with peripheral vasodilator, bronchodilator, and cardiac stimulating properties.

别 称

4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol; Isoprenaline; Norisodrine; Novodrin;  Isoprenalin; Asiprenol

纯 度

≥95%(HPLC)

CAS NO.

7683-59-2

分子式

C¹¹H¹⁷NO³

分子量

211.261

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

棕色或棕褐色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

N/A

水

N/A

l  生物学信息

生物活性/药理作用

Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate  (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Isoproterenol is a synthetic catechol compound and potent beta adrenergic agonist with peripheral vasodilator,  bronchodilator, and cardiac stimulating properties. Isoproterenol exerts its effect on the beta-1 adrenergic receptors in the myocardium, thereby  increasing heart rate and cardiac output. In addition, isoproterenol acts on beta-2 adrenergic receptors in bronchiolar and vascular smooth muscle,  thereby causing smooth muscle relaxation.

l  包装与存储

包 装

50mg; 250mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov