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Bortezomib

商品编号: TL0114
图示 货号 库存 价格(¥) 数量

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质量文档

详细介绍

l  基本信息

产品名称

硼替佐米(Bortezomib)

一般描述

Bortezomib(硼替佐米)  is a dipeptide boronic acid analogue with antineoplastic activity. The mechanism of action of bortezomib is as a Proteasome Inhibitor.

别 称

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; 保特佐米;Velcade; PS-341;  LDP-341

纯 度

≥98%(HPLC)

CAS NO.

179324-69-7

分子式

C19H25BN4O4

分子量

384.243

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Bortezomib is a dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S  proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell  survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.

l  包装与存储

包 装

25mg; 100mg

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov