产品名称

恩替卡韦一水化合物(Entecavir Monohydrate)

一般描述

Entecavir Monohydrate(恩替卡韦一水化合物) is a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV).

别 称

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one;hydrate; Entecavir hydrate

纯 度

≥98%(HPLC)

CAS NO.

209216-23-9

分子式

C¹²H¹⁷N⁵O⁴

分子量

295.299

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Entecavir is a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the  triphosphate form competes with the natural substrate deoxyguanosine  triphosphate (dGTP) for incorporation into viral DNA. The incorporation of  the activated triphosphate metabolite of entecavir inhibits the reverse tranase (RT) viral RNA-dependent HBV DNA polymerase and, so, the  replication of viral DNA and tranion.

l  包装与存储

包 装

25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov