产品名称

异环磷酰胺(Ifosfamide)

一般描述

Ifosfamide(异环磷酰胺) is a synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity.

别 称

N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide; Iphosphamide; Isofosfamide;  Ifosfamid;Isophosphamide

纯 度

≥99%(HPLC)

CAS NO.

3778-73-2

分子式

C⁷H¹⁵Cl²N²O²P

分子量

261.083

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

≥40mg/mL

水

≥40mg/mL

l  生物学信息

生物活性/药理作用

Ifosfamide requires activation by microsomal liver enzymes to active metabolites in order to exert its cytotoxic effects. Activation occurs by hydroxylation at the ring carbon atom  4 to form the unstable intermediate 4-hydroxyifosfamide. This metabolite than  rapidly degrades to the stable urinary metabolite 4-ketoifosfamide. The stable urinary metabolite, 4-carboxyifosfamide, is formed upon opening of the ring. These urinary metabolites have not been found to be cytotoxic. N, N-bis (2-chloroethyl)-phosphoric acid diamide (ifosphoramide) and acrolein are also found. The major urinary metabolites, dechloroethyl ifosfamide and dechloroethyl cyclophosphamide, are formed upon enzymatic oxidation of the chloroethyl side chains and subsequent dealkylation. It is the alkylated metabolites of ifosfamide that have been shown to interact with DNA.  Ifosfamide is cycle-phase nonspecific.

Ifosfamide is a synthetic analogue of the  nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosss, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.

l  包装与存储

包 装

250mg;1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov