产品名称

来那度胺(Lenalidomide)

一般描述

Lenalidomide(来那度胺) is a thalidomide analog with potential antineoplastic activity.

别 称

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Revlimid; Revimid; CC-5013

纯 度

≥99%(HPLC)

CAS NO.

191732-72-6

分子式

C¹³H¹³N³O³

分子量

259.265

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Lenalidomide, a thalidomide analogue, is an immunomodulatory agent possessing immunomodulatory and antiangiogenic  properties. Lenalidomide inhibits the secretion of pro-inflammatory cytokines  and increases the secretion of anti-inflammatory cytokines from peripheral  blood mononuclear cells. Lenalidomide inhibits cell proliferation with  varying effectiveness (IC50s) in some but not all cell lines. Lenalidomide is  effective in inhibiting growth of Namalwa cells (a human B cell lymphoma cell line with a deletion of one chromosome 5) but is much less effective in inhibiting  growth of KG-1 cells (human myeloblastic cell line, also with a deletion of  one chromosome 5) and other cell lines without chromosome 5 deletions. Lenalidomide does not prolong the QTc interval.

Lenalidomide is a thalidomide analog with  potential antineoplastic activity. Lenalidomide inhibits TNF-alpha  production, stimulates T cells, reduces serum levels of the cytokines  vascular endothelial growth factor (VEGF) and basic fibroblast growth factor  (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle  arrest and apoptosis of malignant cells.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov