产品名称

氟维司群(Fulvestrant)

一般描述

Fulvestrant(氟维司群) is a synthetic estrogen receptor antagonist.

别 称

(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; Faslodex;ICI-182780

纯 度

≥98%(HPLC)

CAS NO.

129453-61-8

分子式

C³²H⁴⁷F⁵O³S

分子量

606.777

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Fulvestrant for intramuscular administration is an estrogen receptor antagonist without known agonist effects.

Fulvestrant is a synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells),  fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of  tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.

l  包装与存储

包 装

25mg; 100mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov