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详细介绍
l 基本信息 |
产品名称 | PF04691502 |
一般描述 | PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor. |
别 称 | 2-amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one; PF 04691502; PF-04691502 |
纯 度 | ≥98%(HPLC) | CAS NO. | 1013101-36-4 |
分子式 | C22H27N5O4 | 分子量 | 425.489 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至类白色固体 |
溶解性(25℃) | DMSO | ≥10mg/mL |
乙醇 | Insoluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ,
α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials. |
l 包装与存储 |
包 装 | 5mg; 25mg; 100mg |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
