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详细介绍
l 基本信息 |
产品名称 | AKTI-1/2 |
一般描述 | Akti-1/2 is a highly selective Akt1/Akt2 inhibitor. |
别 称 | 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one; Akt inhibitor VIII |
纯 度 | ≥98%(HPLC) | CAS NO. | 612847-09-3 |
分子式 | C34H29N7O | 分子量 | 551.654 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 褐色固体 |
溶解性(25℃) | DMSO | ≥20mg/mL |
乙醇 | Insoluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Isozyme selective Akt1/2 kinase inhibitor. In in vitro kinase assays, Akt1/2 kinase inhibitor shows IC50 = 58 nM, 210
nM, and 2.12 mM for Akt1, Akt2, and Akt3, respectively, The inhibition appears to be pleckstrin homology (PH) domain-dependent and the Akt1/2 kinase inhibitor has no inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 μM. |
l 包装与存储 |
包 装 | 5mg; 25mg; 100mg |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
