产品名称

多韦替尼碱(Dovitinib)

一般描述

Dovitinib(多韦替尼) is a benzimidazole-quinolinone compound and receptor tyrosine kinase (RTK)inhibitor with potential antineoplastic activity.

别 称

(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one; TKI-258, CHIR-258

纯 度

≥98%(HPLC)

CAS NO.

405169-16-6

分子式

C²¹H²¹FN⁶O

分子量

392.438

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄绿色或绿色固体

溶解性(25℃)

DMSO

≥25mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Dovitinib is a benzimidazole-quinolinone compound and receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Dovitinib binds to and inhibits the phosphorylation of type III-V RTKs, such as vascular endothelial growth factor receptor  (VEGFR) and platelet-derived growth factor receptor (PDGFR) that promote tumor cell proliferation and survival in certain cancer cells. In addition,  this agent also inhibits other members of the RTK superfamily, including  fibroblast growth factor receptor 1 and 3, FMS-like tyrosine kinase 3, stem cell factor receptor (c-KIT), and colony stimulating factor receptor 1. This  may further lead to a reduction of cellular proliferation and angiogenesis, and an induction of tumor cell apoptosis.

l  包装与存储

包 装

5mg; 25mg; 100mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov