产品名称

帕比司他(Panobinostat)

一般描述

Panobinostat(帕比司他), a cinnamic hydroxamic acid analogue, is a novel broad-spectrum inhibitor of HDAC with potential antineoplastic activity.

别 称

(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide;  LBH-589; LBH589; Farydak;

纯 度

≥98%(HPLC)

CAS NO.

404950-80-7

分子式

C²¹H²³N³O²

分子量

349.434

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core  histone proteins, which may result in modulation of cell cycle protein , cell cycle arrest in the G2/M phase and apoptosis. In addition,  this agent appears to modulate the  of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.

l  包装与存储

包 装

5mg; 25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov