产品名称

盐酸米托蒽醌(Mitoxantrone hydrochloride)

一般描述

Mitoxantrone is a type II topoisomerase inhibitor with antineoplastic activity.

别 称

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride;  Mitoxantrone dihydrochloride; Mitoxantrone HCl; Novantrone; Novantron

纯 度

≥97%(HPLC)

CAS NO.

70476-82-3

分子式

C²²H³⁰Cl²N⁴O⁶

分子量

517.404

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

蓝黑色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosss DNA, thereby  disrupting DNA and RNA replication. This agent also binds to topoisomerase  II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

l  包装与存储

包 装

50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov