产品名称

维A酸(Tretinoin)

一般描述

Tretinoin(维A酸), a naturally-occurring acid of retinol, is an important regulator of gene during growth and development, and in neoplasms.

别 称

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid; 视黄酸;  Retinoic acid; Tretinoin; Vitamin A acid; All-trans-Retinoic acid;  Trans-Retinoic acid

纯 度

≥98%(HPLC)

CAS NO.

302-79-4

分子式

C²⁰H²⁸O²

分子量

300.442

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色至淡橙色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol).  Retinoids such as tretinoin are important regulators of cell reproduction,  proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Tretinoin is a naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs),  thereby inducing changes in gene that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of  tretinoin has teratogenic and embryotoxic properties.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov