产品名称

顺苯磺阿曲库铵(Cisatracurium besylate)

一般描述

Cisatracurium besylate is a non-depolarizing skeletal muscle relaxant of the benzylisoquinolinium class, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

别 称

benzenesulfonate;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate;  Nimbex;

纯 度

≥98%(HPLC)

CAS NO.

96946-42-8

分子式

C⁵³H⁷²N²O¹²·2C⁶H⁵O³S

分子量

1243.48

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或黄白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥40mg/mL

l  生物学信息

生物活性/药理作用

Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium  Besylate acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. The neuromuscular block produced by cisatracurium besylate is readily antagonized by anticholinesterase agents once recovery has started.  As with other nondepolarizing neuromuscular blocking agents, the more  profound the neuromuscular block at the time of reversal, the longer the time required for recovery of neuromuscular function. Compared to other  neuromuscular blocking agents, it is intermediate in its onset and duration of action.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov