产品名称

雷帕霉素(Rapamycin(Sirolimus))

一般描述

Rapamycin(雷帕霉素), a macrolide compound obtained from Streptomyces hygroscopicus, is aa mTOR  Inhibitor Immunosuppressant and Kinase Inhibitor.

别 称

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;  西罗莫司;  Sirolimus; AY 22989

纯 度

≥98%(HPLC)

CAS NO.

53123-88-9

分子式

C⁵¹H⁷⁹NO¹³

分子量

914.17

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥15mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Sirolimus, a macrocyclic lactone produced by Streptomyces hygroscopicus, is an immunosuppressive agent indicated for the prophylaxis of organ rejection in patients receiving renal transplants.  It is recommended that sirolimus be used in a regimen with cyclosporine and  corticosteroids.

Sirolimus is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant  properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2,  IL-4, and IL-15) stimulation and inhibition of antibody production.

l  包装与存储

包 装

25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov