产品名称

恩杂鲁胺(Enzalutamide)

一般描述

Enzalutamide(恩杂鲁胺)  is an orally bioavailable, organic, non-steroidal small molecule targeting  the androgen receptor (AR) with potential antineoplastic activity.

别 称

4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide;  MDV3100; MDV-3100; MDV 3100

纯 度

≥99%(HPLC)

CAS NO.

915087-33-1

分子式

C²¹H¹⁶F⁴N⁴O²S

分子量

464.439

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Resitance to enzalutamide therapy has been observed. This may occurred due to an upregulation of NF-κB2/p52.

Enzalutamide is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR)  with potential antineoplastic activity. Through a mechanism that is reported  to be different from other approved AR antagonists, enzalutamide inhibits the  activity of prostate cancer cell ARs, which may result in a reduction in  prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over- in prostate  cancer represents a key mechanism associated with prostate cancer hormone resistance.

l  包装与存储

包 装

50mg; 250mg; 500mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov