产品名称

顺铂(Cisplatin)

一般描述

Cisplatin(顺铂) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA  adducts in tumor cells.

别 称

cis-Diammineplatinum(II) dichloride,  cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride

纯 度

≥99%(HPLC)

CAS NO.

15663-27-1

分子式

Pt(NH³)²Cl²

分子量

300.05

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色或橙黄色固体

溶解性(25℃)

DMF

≥10mg/mL

乙醇

~0.01mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating  agents are so named because of their ability to add alkyl groups to many  electronegative groups under conditions present in cells. They stop tumor growth by cross-ing guanine bases in DNA double-helix strands - directly  attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition,  these drugs add methyl or other alkyl groups onto molecules where they do not  belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific.  Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

l  包装与存储

包 装

50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov